Hematopoietic progenitor cell (HPC) transplantation has become a reliable and effective
means to reconstitute the hematopoietic system after its ablation by chemotherapy
or irradiation. Collection and transplantation are typically coordinated to allow
immediate transplantation for allogeneic units, whereas autologous units are often
cryopreserved for later use [
3
]. In the early 1960s, dimethyl sulfoxide (DMSO) was deemed to be the most effective
of the commonly used permeating cryoprotective agents (CPAs) for HPC cryopreservation
[
1
]. However, despite the efficacy and widespread use of DMSO, it is known to harbor
extensive cytotoxicity and cause adverse reactions in transplant recipients. These
complications can range from acute nausea, vomiting and abdominal cramps, seen in
≤50% of patients, to rare and substantially more serious cardiovascular, respiratory
and neurological issues [
7
].To read this article in full you will need to make a payment
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References
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- Increased haemorrhagic risk after repeated infusion of highly substituted medium molecular weight hydroxyethyl starch.Arzneimittel-forschung. 1997; 47: 18-22
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Article info
Publication history
Published online: October 20, 2021
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© 2021 International Society for Cell & Gene Therapy. Published by Elsevier Inc. All rights reserved.
